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[17] The carbon monoxide tolerance level for any person is altered by several factors, including genetics (hemoglobin mutations), behavior such as activity level, rate of ventilation, a pre-existing cerebral or cardiovascular disease, cardiac output, anemia, sickle cell disease and other hematological disorders, geography and barometric pressure, and metabolic rate

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This is a critical step forward in tobacco harm reduction strategies . Among former smokers, those using combustion-free products reported respiratory symptom levels comparable to those of never-smokers

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